Prof. Keith Matthews is expert on the molecular cell biology of trypanosomatid parasites. His
principal research focus is on the pathogenic trypanosomatid, Trypanosoma brucei. These
cause Human and Animal African Trypanosomiasis in sub-Saharan Africa and he has
investigated their mechanisms of life-cycle regulation in preparation for transmission by the
disease vector (tsetse flies). He has also studied the mechanisms of gene expression control
in these kinetoplastid parasites. These are focused on posttranscriptional processes because
trypanosomatid organisms use polycistronic transcription, precursor RNAs being resolved by
unusual RNA processing mechanisms with differential regulation achieved via mRNA stability
and translational control. Professor Matthews was 2008 recipient of the C. A.
Wright medal from the British Society for Parasitology, elected Fellow of the Royal Society
of Edinburgh in 2014 and Fellow of the Medical Academy of Sciences in 2018. In 2015, he was awarded the Sanofi-Pasteur International mid-career
award for his contributions to the field of tropical medicine and neglected diseases.