My focus is to understand the innate immune responses in different hosts that range from sensing of viruses to terminal IFN effectors mediated by myriad of interferon-stimulated and virus-regulated genes. Employing large-scale, genome-wide and high-throughput screening platforms, my research is deciphering differential host responses to diverse viral pathogens and understanding the bases for genetic resistance/susceptibility of different avian species, virus-host cell interaction, especially how viral and cellular factors regulate the viral replication cycle.