Dr
Sunil
Joshi
I am highly trained and experienced Cellular Immunologist & multi-disciplinary biomedical scientist with >20 years of research and substantial teaching / administration experience. I have been served as University Veterinarian and Primate Immunologist. My major research interest is in investigating “Antigen Cross-presentation and how functional maturation of Dendritic cells influence the interaction with Effector T cells, which determine the outcome of immune response in SELF (autoimmunity) or NON-SELF (cancer, allograft, infections-Malaria, HIV, TB & Influenza) situations? I have also conducted the study on “cellular immune response in P. falciparum-infected humans” in a remote malaria endemic area in India. Since March-2018, I am working on allogeneic BMT through “NKT / MDSC-Cellular Immunotherapy” in preventing allograft rejection and GVHD. As an independent researcher, I am eagerly looking forward to pursue my research on “Novel methods to induce protective immunity against intracellular parasites and cancer”, specifically, DC-based Vaccine for HIV / Malaria / TB and Cancer, based on novel application of quantum mechanics to regulate the metabolomics of DCs.
In the past 20 years, I have worked on a variety of projects in the fields of immunology and infectious diseases, covering innate and adaptive immunity, host-parasite interactions, immune-tolerance, autoimmunity (type I Diabetes), and various genetically modified animal models. My research interests in a broad sense are: molecular and cellular immunology at the interface of host-infectious diseases / cancer interaction, antigen presentation and immune escape mechanisms of pathogens / cancers, and designing targeted novel vaccine strategies towards enhancing specific immunity against various pathogens using humanized mouse and nonhuman primate model (Baboon) of infectious diseases.
“Antigen Cross-presentation and how functional maturation of Dendritic cells influence the interaction with Effector T cells, which determine the outcome of immune response in SELF (autoimmunity) or NON-SELF (cancer, allograft, infections-Malaria, HIV, TB & Influenza) situations?