My current research focuses on intra and inter-host viral diversity and evolution, using high-throughput sequencing to monitor viral evolution both within and between hosts for a range of viruses: FMDV, Rabies, West Nile Virus, Ebola, Classical Swine Fever, Infectious Bronchitis Virus. As part of this I develop computational tools to aid in the visualisation and analysis of viral high-throughput sequence data. I am also working using Synthetical Attenuated Viral Engineering (SAVE) aproaches to deoptimise viral sequences relative to their host (using codon-pair and dinucleotide biases) to generate potential vaccines, and using viral sequence data and biases to predict their hosts, evaluating host adaptation, and determine zoonotic risk.