Professor
Paulo
Bettencourt
Professor at the International Masters in Medicine and Principal Investigator in Immunology and Vaccinology.
The main focus of my research is antigen discovery and vaccine development against tuberculosis, malaria and other intracellular pathogens.
I work on the identification of peptides presented by MHC-I and MHC-II, in infected host cells, using immunopeptidomics (mass spectrometry and bioinformatics), with the purpose of selecting new antigens to be used in the development of vaccines.
My research interests include the study of microRNA expression and function, and the regulatory role these elements have in the context of infection. MicroRNAs provide new answers to old questions, bringing another layer of complexity to immunity, and linking infectious diseases to cancer and metabolic diseases.
By combining the regulation of gene expression with antigen processing and presentation, my goal is to contribute to the development of innovative medical interventions leading to the improvement of global health.
Tuberculosis, Malaria, Antigen Presentation, Mass Spectrometry, Immunopeptidomics, Immunology, Vaccine Design, Vaccinology.