Dr
Alireza
Paradise
Dr
Alireza
Paradise
Head of laboatory
RVSRI
Biography
My name is Alireza Paradise, and I am a dedicated bacteriologist and vaccine researcher based in Karaj, Iran. I currently serve as the Head of the Leptospirosis Laboratory at the Razi Vaccine and Serum Research Institute (RVSRI), where I direct the research and development of vaccines for leptospirosis, a bacterial infection that affects over 1 million animals and humans annually. In this role, I have coordinated with other departments and external partners to ensure the quality, safety, and efficacy of the vaccines, achieving a 90% success rate in clinical trials.
Previously, I was the Head of the Anaerobic Vaccine Research and Production Department at RVSRI from April 2019 to May 2023. During this time, I managed the department, increasing vaccine output by 25% and reducing costs by 15%. I introduced PCR, ultrafiltration, and ELISA techniques to enhance vaccine quality and performance by 20%, preventing the spread of diseases such as enterotoxaemia, black disease, and blackleg disease. I also trained and supervised a team of 20 researchers and technicians, following international standards and regulations, and improving their productivity and satisfaction by 30%.
From December 2006 to April 2019, I served as the Deputy Head of the Anaerobic Vaccine Research and Production Department at RVSRI. In this role, I assisted the head of the department in managing daily operations and activities, overseeing a budget of $2 million and a staff of 50. I conducted and participated in research projects on anaerobic vaccines, publishing 12 papers in reputable journals and presenting at 9 conferences. I also evaluated and reported the results and progress of the research and production processes, identifying and resolving any issues or challenges, and ensuring customer satisfaction and loyalty.
My career at RVSRI began as a staff member of the Anaerobic Vaccine Research and Production Department from December 2006 to April 2014. I performed various tasks related to the research and production of anaerobic vaccines, such as PCR, ultrafiltration, and ELISA, processing over 10,000 samples per month. I maintained the hygiene and safety of the laboratory and the equipment, complying with best practices and guidelines, and reducing the risk of contamination and infection. Additionally, I tutored students in subjects such as bacteriology, microbiology, and immunology, using effective teaching methods and strategies, and helping them improve their grades and test scores by 15%.
I hold a PhD in Bacteriology from BU-Ali Sina University, where I passed all exams with an A score, demonstrating a high level of proficiency and understanding in bacteriology and related fields. I also hold a Doctor of Veterinary Medicine (DVM) from Azad University.
Throughout my career, I have received numerous awards and honors, including the Employee of the Year at RVSRI in 2021 and recognition for my determination and perseverance to promote the culture of research. I hold a patent for a Trivalent Clostridial Toxoid Vaccine, developed in 2019. I have also served as a doctoral dissertation advisor and MSc dissertation advisor, guiding students in their research and development projects.
In addition to my professional achievements, I have contributed to volunteer research activities, including laboratory experiments on the oncolytic activity of Clostridium novyi nontoxic spores in breast cancer. I have co-authored peer-reviewed articles in Bioimpacts and Archives of Razi Institute and have been acknowledged in the doctoral proposal of Dr. Pilehchian Langroudi.
I am passionate about advancing vaccine research and public health, and I am committed to making a positive impact through my work. Research interests
1.Vaccine Development and Immunology:
- Development of novel vaccines for bacterial infections, particularly leptospirosis and anaerobic bacteria.
- Immunogenicity and efficacy studies of vaccines in animal models.
2. Molecular Biology and Biotechnology:
- Application of PCR, ultrafiltration, and ELISA techniques in vaccine research.
- Genetic engineering and production of nano-toxoids.
3. Microbial Pathogenesis and Host-Pathogen Interactions:
- Study of Clostridium species and their toxins.
- Oncolytic activity of bacterial spores in cancer treatment.
4. Public Health and Epidemiology:
- Prevention and control of zoonotic diseases.
- Impact of vaccination programs on public health.
5. Laboratory Management and Quality Control:
- Implementation of international standards and regulations in vaccine production.
- Techniques to enhance laboratory safety and efficiency. Projects you're working on
1. Development of a Multivalent Leptospirosis Vaccine:
- Continue your work on leptospirosis by developing a multivalent vaccine that targets multiple serovars of the bacteria, enhancing its efficacy and coverage.
2. Optimization of Anaerobic Vaccine Production:
- Implement advanced techniques such as CRISPR and next-generation sequencing to further improve the quality and efficiency of anaerobic vaccine production.
3. Oncolytic Bacterial Therapy for Cancer:
- Expand your research on the oncolytic activity of Clostridium novyi spores by exploring their potential in treating different types of cancer and developing targeted delivery systems.
4. **Nano-Toxoid Vaccine Development**:
- Focus on the production of nano-toxoids from Clostridium perfringens beta toxin and other bacterial toxins, aiming to create more effective and safer vaccines.
5. Public Health Impact of Vaccination Programs:
- Conduct epidemiological studies to assess the impact of vaccination programs on the prevalence of zoonotic diseases and develop strategies to improve vaccine uptake and coverage.
6. Quality Control and Safety in Vaccine Production:
- Develop and implement new quality control protocols and safety measures in vaccine production to ensure compliance with international standards and enhance overall efficiency.
Discipline
Bacteriology Bio-manufacturing Challenge study design Clinical trials – efficacy Clinical trials – safety Ethics Immunology – B-cells QC test development Quality assurance Host species
Cats Cattle Dogs Horses Poultry Zoonoses Pathogen
Bacteria Bacteria›Brucella Bacteria›Clostridia Bacteria›Corynebacterium Bacteria›E. coli Bacteria›Leptospira Bacteria›Mycoplasma Stage of vaccine development
Adjuvants Antigen discovery and immunogen design Clinical trials Field trials Vaccine delivery